Publications (Link to Google Scholar Page)

Pagendarm, HM, Stone, PT, et al. Engineering endosomolytic nano carriers of diverse morphologies using confined impingement jet mixing. Nanoscale. (2023). doi:https://doi.org/10.1039/D3NR02874G

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Wang-Bishop L, Kimmel, BR, et al. STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy. Science Immunology. (2023). doi: 10.1126/sciimmunol.add1153

Florian DC, et al. Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction. Cancer Research Communications. (2023). doi: 10.1158/2767-9764.CRC-22-0180

De Mel J, et al. Dual-Responsive Glycopolymers for Intracellular Codelivery of Antigen and Lipophilic Adjuvants. Molecular Pharmaceutics. (2022). doi: 10.1021/acs.molpharmaceut.2c00750

Suryadevara N, Kumar A, Ye X, Rogers M, Williams JV, Wilson JT, Karijolich J, Joyce S. A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination. Scientific Reports. (2022). doi: 10.1038/s41598-022-21620-7

Baljon, JJ, Wilson JT. Bioinspired vaccines to enhance MHC class-I antigen cross-presentation. Current Opinion in Immunology. (2022). doi: 10.1016/j.coi.2022.102215

Carson CS, et al. A nanovaccine for enhancing cellular immunity via cytosolic co-delivery of antigen and polyIC RNA. J. Control. Release. (2022).

doi: 10.1016/j.jconrel.2022.03.020.

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Garland KM*, Sheehy TL*, Wilson JT. Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy. Chemical Reviews. (2022)

doi: 10.1021/acs.chemrev.1c00750.

Sharma J, Carson CS, Douglas T, Wilson JT, Joyce S. Nano-Particulate Platforms for Vaccine Delivery to Enhance Antigen-Specific CD8+ T-Cell Response. Methods Mol Biol. (2021)

doi: 10.1007/978-1-0716-1892-9_19.

Garland KM, Rosch JC, Carson CS, Wang-Bishop L, Hanna A, Sevimli S, Van Kaer C, Balko JM, Ascano M, Wilson JT. Pharmacological Activation of cGAS for Cancer Immunotherapy. Front. Immunol. (2021)

doi: 10.3389/fimmu.2021.753472.

Wilson JT, Lund AW. Building new roads to stronger immunity. Sci Adv. (2021)

doi: 10.1126/sciadv.abh3971.

Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A. A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery. Commun Biol. (2021)

doi: 10.1038/s42003-021-01728-8.

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Ulkoski D, Munson MJ, Jacobson ME, Palmer CR, Carson CS, Sabirsh A, Wilson JT, Krishnamurthy VR. High-Throughput Automation of Endosomolytic Polymers for mRNA Delivery. ACS Appl. Bio Mater. (2021) doi: 10.1021/acsabm.0c01463.

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Knight FC, Wilson JT. Engineering Vaccines for Tissue-Resident Memory T Cells. Adv. Therap. (2021)

doi: 10.1002/adtp.202000230.

Nguyen DC, Shae D, Pagendarm HM, Becker KW, Wehbe M, Kilchrist KV, Pastora LE, Palmer CR, Seber P, Christov PP, Duvall CL, Wilson JT. Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists. Adv. Healthc. Mater. (2020). doi: 10.1002/adhm.202001056.

Wehbe M, Wang-Bishop L, Becker KW, Shae D, Baljon JJ, He X, Christov PP, Boyd KL, Balko JM, Wilson JT. Nanoparticle delivery improves the pharmacokinetic properties of cyclic dinucleotide STING agonists to open a therapeutic window for intravenous administration. J Control Release. (2020). doi: 10.1016/j.jconrel.2020.11.017.

Jacobson ME, Becker KW, Palmer CR, Pastora LE, Fletcher RB, Collins KA, Fedorova O, Duvall CL, Pyle AM, Wilson JT. Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists. ACS Cent. Sci. (2020). doi: 10.1021/acscentsci.0c00568.

Shae D*, Baljon JJ*, Wehbe M, Christov PP, Becker KW, Kumar A, Suryadevara NC, Carson CS, Palmer CR, Knight FC, Joyce S, Wilson JT. Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines. ACS Nano. (2020). doi: 10.1021/acsnano.0c02765.

Kumar A, Suryadevara NC, Wolf KJ, Wilson JT, Di Paolo RJ, Brien JD, Joyce S. Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model. Sci. Rep. (2020). doi: 10.1038/s41598-020-69897-w.

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Wang-Bishop L, Wehbe M, Shae D, James J, Hacker BC, Garland K, Chistov PP, Rafat M, Balko JM, Wilson JT. Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma. JITC (2020). doi: 10.1136/jitc-2019-000282.

Ou Y-C, Wen X, Johnson C, Shae D, Ayala OD, Webb JA, Lin EC, DeLapp RC, Boyd KL, Richmond A, Mahadeven-Jansen A, Rafat M, Wilson JT, Balko JM, Tantawy MN, Vilgelm AE, Bardhan R. Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies. ACS Nano (2019). doi: 10.1021/acsnano.9b07326.

Knight FC, Gilchuk P, Kumar A, Becker KW, Sevimli S, Jacobson ME, Suryadevara NC, Wang-Bishop L, Boyd KL, Crowe JE, Joyce S, Wilson JT. Mucosal Immunization with a pH-Responsive Nanoparticle Vaccine Induces Protective
CD8+ Lung-Resident Memory T Cells. ACS Nano 13: 10939-10960 (2019).

Ulkoski D, Bak A, Wilson JT, Krishnamurthy VR. Recent Advances in Polymeric Materials for the Delivery of RNA Therapeutics. Expert Opinion on Drug Delivery 16:1149-1167 (2019).

Shae D, Baljon JJ, Wehbe M, Becker KW, Sheehy TL, Wilson JT. At the Bench: Engineering the Next Generation of Cancer Vaccines. Journal of Leukocyte Biology (2019). doi/abs/10.1002/JLB.5BT0119-016R.

Garland KM*, Sevimli S*, Kilchrist KV, Duvall CL, Cook RS, Wilson JT. Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles. Cellular and Molecular Bioengineering (2019)

doi.org/10.1007/s12195-019-00571-6.

Part of 2019 CMBE Young Innovators special issue

Baljon JJ, Dandy A, Wang-Bishop L, Wehbe M, Jacobson ME, Wilson JT. The Efficiency of Cytosolic Drug Delivery Using Endosomolytic Polymers Does Not Correlate with Activation of the NLRP3 Inflammasome. Biomaterials Science 7:1888-1897 (2019).

Wilson JT. A Sweeter Approach to Vaccine Design.

Science. 363:584-584 (2019).

Shae D, Becker KW, Chistov P, Yun D-S, Lytton-Jean A, Sevimli S, Ascano M, Kelley M, Johnson D, Balko J, Wilson JT. Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy. Nature Nanotechnology 14:269-278 (2019).

see News & Views article:

Hubbell JA, Swartz MA. Trojan Horses for Immunotherapy. Nature Nanotechnology 14:196-197 (2019).

Jacobson ME, Wang-Bishop L, Becker KW, Wilson JT. Delivery of 5’-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer Immunotherapy. Biomaterials Science. 7:547-559 (2019).

Part of 2019 Biomaterials Science Emerging Investigators special issue

Elion D, Jacobson M, Hicks D, Rahman B, Sanchez V, Gonzalez-Ericsson P, Fedorova P, Pyle A, Wilson JT, Cook RS. Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers. Cancer Research. 78:6183-6195 (2018).

Qiu F, Becker KW, Knight FC, Baljon JJ, Shae D, Gilchuk P, Joyce S, Wilson JT. Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines. Biomaterials.1 82:82-91 (2018).

Palmer CR, Jacobson ME, Fedorova O, Pyle AM, Wilson JT. Environmentally Triggerable RIG-I Agonists Using Synthetic Polymer Overhangs. Bioconjugate Chemistry. 29:742-747 (2018).

Sevimli S, Knight F, Gilchuk P, Joyce S, Wilson JT. Fatty Acid-Mimetic Micelles for Dual-Delivery of Antigens and Imidazoquinoline Adjuvants. ACS Biomaterials Science & Engineering. 3:179-194 (2017).

Ou Y-C, Webb JA, Faley S, Shae D, Talbert EM, Lin S, Cutright C, Wilson JT, Bellan LM, Bardhan R. Gold Nanoantenna-Mediated Photothermal Drug Delivery from Thermosensitive Liposomes in Breast Cancer. ACS Omega. 1:234-243 (2016).

Shae D, Postma A, Wilson JT. Vaccine Delivery: Where Polymer Chemistry Meets Immunology. Therapeutic Delivery. 7:193-6 (2016).

Gilchuk P, Knight FC, Wilson JT, Joyce S. (2016) “Eliciting epitope-specific CD8 T cell response by immunization with microbial proteinantigens formulated with alpha-galactosylceramide: theory, practice, & protocols.” In C.B. Fox ed. Methods in Molecular Biology: Vaccine Adjuvants — Methods and Protocols. New York, NY: Springer Science & Business Media, LLC.

Graham DJ, Wilson JT, Lai JJ, Stayton PS, Castner DG. 3D Localization of Polymer Nanoparticles in Cells Using ToF-SIMS. Biointerphases.11:02A304 (2016).

Gilchuk P, Hill TM, Wilson JT, Joyce S. Discovering Protective CD8 T Cell Epitopes – No Single Immunologic Property Predicts It! Current Opinion in Immunology. 34:43-51 (2015).

Lane DD, Su FY, Chiu DY, Srinivasan S, Wilson JT, Ratner DM, Stayton PS, Convertine AJ. Dynamic Intracellular Delivery of Antibiotics via pH-Responsive Polymersomes. Polymer Chemistry. 6:1255-1226 (2015).

Wilson JT, Postma A, Keller S, Convertine AJ, Moad G, Rizzardo E, Chiefari J, Stayton PS. Enhancement of MHC-I Antigen Presentation via Architectural Control of pH-Responsive Endosomolytic Polymer Nanoparticles. The AAPS Journal. 17:358-369 (2015).

Wilson JT, Chaikof EL (2014). “Molecular Engineering of Cell and Tissue Surfaces with Polymer Thin Films.” In: Zhao W & Karp JM eds. Micro- and Nanoengineering the Cell Surface, 1st Edition.New York, NY: Elsevier.

Keller S, Wilson JT, Patelia GI, Kern HB, Convertine AJ, Stayton PS. Neutral Polymer Micelle Carriers with pH-Responsive, Endosome-Releasing Activity Modulate Antigen Trafficking to Enhance CD8(+) T Cell Responses. Journal of Controlled Release. 191:24-33 (2014).

Wilson JT, Keller S, Manganiello MJ, Cheng C, Lee C-C, Opara C, Convertine AJ, Stayton PS. pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides. ACS Nano. 7:3912-3925 (2013).

Prior to 2013:

Mets JM, Wilson JT, Cui W, Chaikof EL. An automated process for layer-by-layer assembly of polyelectrolyte multilayer thin films on viable cell aggregates. Advanced Healthcare Materials2:266-270 (2013)
Stayton PS, Ghosn B, Wilson JT(2012), “Finding the ‘Magic Bullet’: Targeting Carriers for Drug Delivery." In: Ratner BD, Hoffman AS, Schoen FJ, & Lemons JE eds. Biomaterials Science: An Introduction to Materials in Medicine, 3rd Edition. New York, NY: Elsevier/Academic Press.
Wilson JT, Cui W, Kozlovskaya V, Kharlampieva E, Pan D, Qu Z, Mets J, Kumar V, Krishnamurthy V, Song Y, Tsukruk VV, Chaikof EL. Cell surface engineering with polyelectrolyte multilayer thin films. Journal of the American Chemical Society133:7054-64 (2011).
Krishnamurthy VR, Wilson JT, Cui W, Song X, Lasanajak Y, Cummings RD, Chaikof EL. Chemoselective immobilization of peptides on abiotic and cell surfaces at controlled densities. Langmuir26:7675-8 (2010).
Wilson JT, Haller CA, Qu Z, Cui W, Urlam MK, Chaikof EL. Biomolecular surface engineering of pancreatic islets with thrombmodulin. Acta Biomaterialia6:1895-903 (2010).
Wilson JT, Krishnamurthy VR, Qu Z, Cui W, Chaikof EL. Non-covalent cell surface engineering with cationic graft copolymers. Journal of the American Chemical Society51:18228-9 (2009).
Cui W,Wilson JT, Wen J, Angsana J, Qu Z, Haller CA, Chaikof EL. Thrombomodulin improves early outcomes after intraportal islet transplantation. American Journal of Transplantation9: 1308-16 (2009).
Wilson JT, Chaikof EL. Thrombosis and inflammation in intraportal islet transplantation: a review of pathophysiology and emerging therapeutics. Journal of Diabetes Science and Technology2: 746-59 (2008).
Wilson JT, Cui W, Chaikof EL. Layer-by-layer assembly of a conformal nanothin PEG coating for intraportal islet transplantation. Nano Letters8: 1940-1948 (2008). (Highlighted in July 10, 2008 issue of Science-Business eXchange (SciBX), a Nature and BioCentury publication that focuses on translational research)
Wilson JT, Chaikof EL. Challenges and emerging technologies in the immunoisolation of cells and tissues.Advanced Drug Delivery Reviews60: 124-45 (2008).
Stabler CL, Sun X-L, Cui W, Wilson JT, Haller CA, Chaikof EL. Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin. Bioconjugate Chemistry 18: 1713-5 (2007). (cover article)
Wilson JT, Cui W, Sun X-L, Tucker-Burden C, Weber CJ, Chaikof EL. In vivo biocompatibility and stability of a substrate-supported polymerizable membrane-mimetic film. Biomaterials28: 609-617 (2007).
Dai Z, Wilson JT, Chaikof EL. Construction of PEGylated multilayer architectures via (strept)avidin/biotin interactions. Materials Science and Engineering C27: 402-408 (2007).
Bower CK, Parker JE, Higgins AZ, Oest ME, Wilson JT, Valentine BA, Bothwell MK, McGuire J. Protein antimicrobial barriers to bacterial adhesion: in vitroand in vivoevaluation of nisin-treated implantable materials. Colloids and Surfaces B: Biointerfaces25: 81-90 (2002).

Publications (Link to Google Scholar Page)

Prior to 2013:

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